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Reassessing your supplement protocol is a biological necessity — not a whim

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I reassess my supplement protocol every single month.

I spend about 4 hours over a weekend doing so. This does not include the time spent reading and analyzing studies throughout the month.

This approach may surprise some people, but it is based on a very simple biological reality:

👉 The human body is not a static system.

Needs evolve depending on:

• environmental stressors (toxins, infections, travel, mycotoxins)

• inflammatory status

• gut permeability

• mitochondrial function

• autonomic nervous system balance

• and the adaptations induced by the supplements themselves

  

  

A protocol that made perfect sense three months ago can become useless, excessive — or even counterproductive — today.

To those who believe that “eating well is enough,” my answer is twofold:

First, our soils are severely depleted, meaning the foods we eat today are far less nutrient-dense than they once were.

Second, while a perfectly balanced diet allows you to live a normal life, a balanced diet plus intelligent supplementation allows you to live an optimal life.

The physiological reasons behind changes in my protocol

Monthly adjustments are mainly driven by three situations:

1. A therapeutic objective has been reached

Example: targeted work on mycotoxins, which becomes unnecessary once biomarkers return to normal. I still have the OTAs to take care of though.

2. Controlled exploration of new molecules

Some emerging supplements show interesting mechanisms of action (mitochondrial, inflammatory, neuro-immune). I choose to test them in a measured, monitored, and controlled framework.

3. Conditions poorly or insufficiently addressed by conventional medicine

Or situations where I aim to avoid treatments with heavy side effects, when structured alternatives exist.

This protocol is personal, experimental, and monitored

The protocol presented here is strictly my own.

It is:

• not a recommendation

• not a model to replicate

• not medical advice

It is an individual case, based on:

• specific medical history

• specific symptoms

• biomarkers that are regularly tracked

I share it solely because so many of you ask me what I take, why I take it, and how.

Prescription molecules: framework and precautions

This protocol intentionally includes prescription-only molecules, known for their powerful systemic effects.

Example: colchicine

It is used here to modulate chronic inflammation, notably via inhibition of the NLRP3 inflammasome pathway, which is now well documented in inflammatory, metabolic, and neurodegenerative conditions.

👉 But colchicine is not benign:

• it can impact pancreatic function

• it requires regular lipase monitoring

In my case:

• a moderate elevation in lipase led to an initial 75% dose reduction

• that reduction was accompanied by a rebound in inflammatory markers

• a subsequent adjustment to 50% of the dose was then implemented

This is exactly how any serious approach should work:

observe → measure → adjust → reassess

Formulation logic: absorption and digestive load

One often overlooked aspect: the form of supplements.

Whenever possible, I favor:

• powders

• liquid forms

• transdermal forms

Objectives:

• reduce digestive burden

• improve bioavailability

• avoid excessive capsule ingestion (currently ~80–100/day)

“What about your liver? Your kidneys?” — a biological answer, not an emotional one

This question comes up often — sometimes sarcastically — often from people sipping cocktails or enjoying processed foods.

My answer is simple:

👉 I measure.

• Liver function

• Kidney function

• Inflammatory markers

Everything is tracked and documented.

And most importantly:

I publish the results — unfiltered, no storytelling, no spin.

Supplement quality: a central issue

The scientific literature is clear:

👉 Supplement quality varies enormously.

That is why:

• I detail my choices on valbiohacker

• I am using as much as I can my own products though my line is very short on ZellNova.com (made in the USA, no fillers, clean).

  

  

Few products, but:

• verified manufacturing chains

• maximum traceability

• coherence with a serious biohacking approach

April protocol: intentionally restricted access

The detailed protocol (timing, dosages, combinations, prescription molecules) is placed behind a paywall.

Not out of elitism.

But to avoid:

• superficial reading

• misuse

• and, above all, dangerous misinterpretations

👉 Only those truly committed to understanding can access it.

In this protocol, you will not see the BioBloom NADH patches I use twice per week.
Nor will you see the SomaPeptides peptides I use under fairly complex protocols.
Follow the links to access the exclusive discounts I negotiated for you.

Those require a dedicated article.

If peptides interest you, head to the PEPTIDES section on valbiohacker.com

Why this protocol is heavily modified this month

The past six months were focused on mycotoxins (I eliminated all of them except one originating from tea, spices, alcohol, and coffee).

As a result, for April I reduced all binders (chelators) to zero except for charcoal which I am keeping in the morning.

I also aimed to eradicate salmonella without antibiotics, which I successfully achieved based on my latest test results.

Therefore, several supplements are no longer necessary (like oregano oil).

I have also removed all biofilm disruptors for now as I am embarking on a long 3-month trip and I cannot take every single supplement.

Here is my updated list:

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For a long time, I kept astragalus at arm’s length.

A “traditional” plant, used for centuries in Chinese medicine, often lumped into the somewhat vague category of adaptogens. Interesting… but not enough, in my mind, to earn a place in a serious longevity protocol.

And then—like so often in biohacking—it was the data that changed my perspective… and the length of my telomeres, which went from 6.1 kb to 7.0 kb.

So yes, it seems astragalus is effective. But… there are astragalus products that are completely ineffective, others that can be problematic, and timing and dosage matter. Let’s break it down.

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Reassessing your supplement protocol is a biological necessity — not a whim

Share

I reassess my supplement protocol every single month.

I spend about 4 hours over a weekend doing so. This does not include the time spent reading and analyzing studies throughout the month.

This approach may surprise some people, but it is based on a very simple biological reality:

👉 The human body is not a static system.

Needs evolve depending on:

• environmental stressors (toxins, infections, travel, mycotoxins)

• inflammatory status

• gut permeability

• mitochondrial function

• autonomic nervous system balance

• and the adaptations induced by the supplements themselves

A protocol that made perfect sense three months ago can become useless, excessive — or even counterproductive — today.

To those who believe that “eating well is enough,” my answer is twofold:

First, our soils are severely depleted, meaning the foods we eat today are far less nutrient-dense than they once were.

Second, while a perfectly balanced diet allows you to live a normal life, a balanced diet plus intelligent supplementation allows you to live an optimal life.

The physiological reasons behind changes in my protocol

Monthly adjustments are mainly driven by three situations:

1. A therapeutic objective has been reached

Example: targeted work on mycotoxins, which becomes unnecessary once biomarkers return to normal.

2. Controlled exploration of new molecules

Some emerging supplements show interesting mechanisms of action (mitochondrial, inflammatory, neuro-immune). I choose to test them in a measured, monitored, and controlled framework.

3. Conditions poorly or insufficiently addressed by conventional medicine

Or situations where I aim to avoid treatments with heavy side effects, when structured alternatives exist.

This protocol is personal, experimental, and monitored

The protocol presented here is strictly my own.

It is:

• not a recommendation

• not a model to replicate

• not medical advice

It is an individual case, based on:

• specific medical history

• specific symptoms

• biomarkers that are regularly tracked

I share it solely because so many of you ask me what I take, why I take it, and how.

Prescription molecules: framework and precautions

This protocol intentionally includes prescription-only molecules, known for their powerful systemic effects.

Example: colchicine (thank you Dr. Gina Tobalina for pointing me in this direction).

It is used here to modulate chronic inflammation, notably via inhibition of the NLRP3 inflammasome pathway, which is now well documented in inflammatory, metabolic, and neurodegenerative conditions.

👉 But colchicine is not benign:

• it can impact pancreatic function

• it requires regular lipase monitoring

In my case:

• a moderate elevation in lipase led to an initial 75% dose reduction

• that reduction was accompanied by a rebound in inflammatory markers

• a subsequent adjustment to 50% of the dose was then implemented

This is exactly how any serious approach should work:

observe → measure → adjust → reassess

Formulation logic: absorption and digestive load

One often overlooked aspect: the form of supplements.

Whenever possible, I favor:

• powders

• liquid forms

• transdermal forms

Objectives:

• reduce digestive burden

• improve bioavailability

• avoid excessive capsule ingestion (currently ~80–100/day)

“What about your liver? Your kidneys?” — a biological answer, not an emotional one

This question comes up often — sometimes sarcastically — often from people sipping cocktails or enjoying processed foods.

My answer is simple:

👉 I measure.

• Liver function

• Kidney function

• Inflammatory markers

Everything is tracked and documented.

And most importantly:

I publish the results — unfiltered, no storytelling, no spin.

Supplement quality: a central issue

The scientific literature is clear:

👉 Supplement quality varies enormously.

That is why:

• I detail my choices on valbiohacker

• I am working on an upcoming super clean supplement line called ZellNova (make sure you follow to be the first to know when the doors open!)

Few products, but:

• verified manufacturing chains

• maximum traceability

• coherence with a serious biohacking approach

January protocol: intentionally restricted access

The detailed protocol (timing, dosages, combinations, prescription molecules) is placed behind a paywall.

Not out of elitism.

But to avoid:

• superficial reading

• misuse

• and, above all, dangerous misinterpretations

👉 Only those truly committed to understanding can access it.

In this protocol, you will not see the BioBloom NADH patches I use twice per week.
Nor will you see the SomaPeptides peptides I use under fairly complex protocols.
Follow the links to access the exclusive discounts I negotiated for you.

Those require a dedicated article.

If peptides interest you, head to the PEPTIDES section on valbiohacker.com

Why this protocol is heavily modified this month

The past six months were focused on mycotoxins (I eliminated all of them except one originating from tea, spices, alcohol, and coffee).

As a result, for January I reduced all binders (chelators) to zero:

• bentonite clay

• activated charcoal

• zeolite

I also aimed to eradicate salmonella without antibiotics, which I successfully achieved based on my latest test results.

Therefore, several supplements are no longer necessary.

That said, I am keeping biofilm disruptors and antimicrobials for two more weeks (post-therapeutic plasma exchange).

Here is my updated list:

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It’s often presented as a gentle, almost harmless herb — a natural anti-stress solution anyone can take without thinking too much.

Ashwagandha is not a neutral supplement. When poorly sourced, improperly standardized, overdosed, or taken without understanding its physiology, it can be ineffective — or counterproductive. And yet, low-quality ashwagandha products dominate the market: vague formulations, inconsistent potency, contamination risks, and exaggerated claims.

Behind this ancient root lies a powerful botanical, capable of modulating the HPA axis, influencing cortisol, sleep architecture, thyroid signaling, and overall neuroendocrine balance — for better or worse.

This article is for people who prefer understanding before supplementing.

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The answer isn’t a simple yes or no—it depends entirely on the mechanism of action, your body’s adaptive response, and your specific optimization goals.

Let’s explore the science behind cycling, which interventions benefit from breaks, and which ones you should maintain consistently for optimal longevity outcomes.

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After months of experimenting with different hacks and supplements, I finally found a compound I now consider indispensable.

I’d known about it by name for years, but I had never really integrated it into my routine.

That changed after attending the longevity conference RAADFest in Las Vegas.

My biohacker friend Rachael shared her story: after years of failed attempts (every new method worked for a few days, then stopped), this supplement had completely transformed her sleep — and two years later, it was still working.

Intrigued, I tried it. And wow… I was blown away! 🌙 Even my super warriors, like Djamila, told me: “It’s crazy how much this has transformed my deep sleep!”

With my other hacks, I had already extended my deep sleep from 20 minutes to 45 minutes, then to an hour, and eventually to 90 minutes. Now, even when my night is very short (overnight flights, jet lag, etc.), I always manage to get at least 90 minutes of deep sleep!

So, I couldn’t keep this secret to myself any longer. Here’s everything: what it is, how it works, and how much to take.

✨ So… tadaaaa… re-tadaaaa… I’m talking about:

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Today, I’ve decided to play the transparency card and share with you my most recent results 📊.

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This article comes in response to the requests you’ve made on our Chat thread. Feel free to ask your questions directly on this page and I’ll answer them.

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We all have to start somewhere… The vast majority of people around me either take nothing at all, or (worse) a cheap, low-quality multivitamin, or maybe a little vitamin C here and there, “just in case.”

And so many of you ask me:

“If I could only take three supplements, which ones should I choose?”

Three is an absurdly small number when we’re talking about cellular optimization.

Important note: None of the brands mentioned here paid me to feature them.

Realistically, you’d need at least ten to address the most common deficiencies of our modern lifestyle (and I NEVER base my recommendations on outdated RDA standards) and to truly protect your cells.

But let’s embrace the challenge: here are my 3 favorite supplements for 3 vital pillars:

1. Immunity & Antioxidation

2. Regeneration & Repair

3. Genetic Longevity

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This article comes directly from one of your questions in our Chat Thread. Don’t hesitate to drop your own questions there — that’s exactly what I created it for. Once I take care of your request, I remove it. It’s a simple as that!

Unlike leucine or glutamine, this amino acid is not directly incorporated into proteins. Instead, it plays a key role in nitric oxide (NO) production, blood circulation, muscle performance, and even cognitive function.

It’s so important that I often wonder why it isn’t talked about more!

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One day I asked myself a very simple question: since fish get their omega-3s from eating algae… why not go straight to the source? Not only would this avoid killing fish, but cultivating algae is far less energy- and resource-intensive for our planet.

On one hand, fish oil is a traditional and well-researched source of EPA and DHA—two essential fatty acids that support our brain, heart, and cellular health. On the other, algae oil is a newer product on the market, but it promises purity, sustainability, and ethics.

So, between tradition and innovation, between the sea and the bioreactor, which omega-3 oil truly deserves a place in our health protocol? I dug into the question, compared the two, and here’s the verdict…

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In the biohacking world, there are those who follow ultra-precise protocols and cutting-edge technologies, and those who lean towards more natural products, including certain compounds from Ayurvedic medicine.

I like to say that just because something is “ancient” doesn’t mean it’s better for us. And just because an active compound comes from the depths of the Himalayas or a high-altitude meadow in Peru doesn’t mean it’s miraculous—or even safe.

But let’s get back to shilajit. Given the growing number of people taking it, the many celebrity names, influencers, and biohackers who talk about it and use it regularly, I decided to investigate!

At first glance, shilajit seems like a mysterious, powerful natural ingredient gaining more and more attention in the health and wellness space.

Used for thousands of years in traditional Ayurvedic medicine, this ancient remedy is often called the “conqueror of mountains” or “destroyer of weakness.”

So—good or bad? Miracle or marketing hype?

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Why you NEED to care about creatine, even if you’re not a bodybuilder

Think creatine is only for gym rats and bodybuilders?
Big mistake.

And I’m not the only one.

Recent studies reveal spectacular effects on cognition, neurodegenerative disease prevention (like Alzheimer’s), and even mood.

But beware: if you choose the wrong form or dose it poorly, creatine can become useless — or even counterproductive.
Ready to separate fact from fiction? 👇

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I’ll humbly admit I had never heard of this molecule before, and I dove into a lot of reading before forming my opinion.

And I must say — I was surprised by what I discovered!

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You’ve probably heard that phrase, especially from people who sip wine every evening 🍷😉 But in the world of biohacking, where supplementation can be powerful and purposeful, it’s important to ask:

🧠 Is there a real risk for the liver? Or just another myth?

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My father is 84. And he looks 10 years younger, thanks to his efforts.

So my dad is in full “I’m changing how my genes express themselves” mode (yes, the famous epigenetics you’ve heard about).

Honestly, nothing frustrates me more than people diagnosed with a serious condition who don’t do everything they can to change the game… who stay passive in the face of a bleak prognosis. I’m not saying you can change 100% of everything, obviously. But often, we have tools to slow things down, make them more bearable, or even reverse the course.

Diagnosed 18 years ago with emphysema, doctors gave my dad less than 6 months to live.

Today, he hikes or swims several hours a day, lives an active, biohacker lifestyle, and refuses to be defined by a medical label.

📲 Check out my Instagram series called “Super Dad,” where I share his hacks (simple but powerful tricks to stay fit, youthful, and active despite age).

💪 And for the first time,

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✨ For a long time, I believed digestive enzymes only played a role during meals. But the latest research led me to add proteolytic enzymes to my biohacking routine — on an empty stomach.

And the results went far beyond what I expected.

Today, I’m sharing why these enzymes can be a game-changer for recovery, inflammation, and even longevity.

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More vitamins don’t mean better health. Learn how to avoid toxic overdoses and supplement combinations that work against your biohacking goals.

💊 Do you take several supplements daily? (I take over 35, so my answer is yes!)

Vitamins, minerals, cognitive boosters, natural anti-inflammatories…
But do you actually know which doses are safe?

And more importantly: which combinations may be counterproductive or even harmful to your health?

In this article, I’ll reveal:

• Which vitamins pose toxicity risks (even “natural” ones)

• Hidden supplement interactions even experts overlook

• Simple rules for building an effective, safe routine — without rebound effects or metabolic overload

🎯 Biohacking is about precision,
🔍 not blind accumulation.

👉 To read the full article and access my compatibility chart + safe protocols, sign in or subscribe at ValBiohacker.com

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