By Valérie Orsoni — Biohacker & Longevity Expert
Valérie Orsoni is a biohacker, author of 56 books, and founder of biohacker.fr. She has been tracking her biology through N=1 self-experimentation protocols since 1998. She has completed a Stanford Genetics Longevity Research certificate, two Stanford Medicine certificate programs: Nutrition Science and GLP-1s & weight loss. She is currently enrolled in a Stanford Geneticas & AI certification program. She was named in the Top 50 Longevity Leaders by Life Spanning magazine and is currently the #1 on the Longevity Cup Leaderboard (chronological age -23 years).
Fifty years of gut trouble, SIBO, IBS, pathogens...
50.
Fifty.
25+25.
That’s a lot.
I have consulted dozens of gut specialists, all over the world.
SIBO, IBS, and more... according to the doctors, I have it all.
SIBO is an overgrowth of bacteria in the small intestine, which can cause bloating, gas, abdominal pain and bowel problems.
Every time, the same sentence: “I know what needs to be done.”
And every time, it didn’t work.
Before I tell you about this experiment, let me answer the question I get every single time: “Have you tried that?”
Yes. Over fifty years, since I was very young, I have tried:
• antibiotics, of every kind;
• all sorts of supplements, from oregano oil to lumbrokinase and many more;
• prebiotics, probiotics and postbiotics, also of every kind;
• the elemental diet, in three versions, including one formulated by one of the doctors treating me (very well known for his success in this field);
• short fasts, longer fasts, and even a 72-hour fast (oh, and please don’t tell me the 7-day fast is missing from my list!);
• stress management, from heart coherence breathing to breathing exercises and meditation;
• eliminating all FODMAPs, gluten and dairy, then reintroducing them;
• other eliminations carefully calculated by these experts;
• eating everything, but in small amounts;
• eating only twice a day;
• eating six times a day;
• eating only once a day;
• a raw food diet, a strict medically supervised keto diet, and a whole host of other approaches;
• and other things I’ve surely forgotten.
And yes, I also had my DNA analyzed (whole genome sequencing). What my genes say about my gut, I reveal further down. I didn’t see it coming.
The only thing I haven’t tried yet: fecal microbiota transplantation. I’ll admit I’m not very motivated for now.
Fifty years of testing new approaches. My parents couldn’t understand why my stomach always hurt. We did find a tiny fennel allergy and an intolerance to what would later be called FODMAPs, but nothing more.
And nothing worked.
In October 2025, I decided to do exactly the opposite of what we’ve always been told in nutrition.
After years of digestive problems, consultations and protocols with no lasting solution, I had one question in mind.
To answer it, I radically changed what was on my plate for twelve weeks.
I didn’t see what came next coming. If you also feel like you’ve tried everything... this piece is for you.