How to Thicken Skin, Plump It, and Reduce Wrinkles, and the $10 serum that will transform your skin

For the past 30 years I have tried pretty much everything under the sun to fight aging skin, even salmon sperm!

By Valérie Orsoni — Biohacker & Longevity Expert
Valérie Orsoni is a biohacker, author of 56 books, and founder of biohacker.fr. She has been tracking her biology through N=1 self-experimentation protocols since 1998. She is recently completed her Stanford Genetics Longevity Research certification program and is currently enrolled in the Stanford Medicine nutrition science program.
She was named in the Top 50 Longevity Leaders by Life Spanning magazine and is currently the #1 on the Longevity Cup Leaderboard (chronological age -23 years).

Faire warning: This is a very long article with tons of resources. Hope you will like it!

I get this question more than any other, and it almost always arrives in the same shape: what’s the one thing?

There isn’t one. But there is a hierarchy, and almost nobody publishes it honestly — because the things at the top are unglamorous and cheap, and the things people want to sell you sit in the middle.

This article is long and full of references and products/modalities that work (and those which don’t). So take some time away from work, sit down, and read slowly…..this is YOUR time.

Here is the real ranking, built from twenty years of reading the literature and testing on myself. I’ll tell you what has human randomized trials behind it, what has plausible mechanism and no human data, and what is being sold to you on the strength of a mouse study and good graphic design.

I’m also going to tell you about a $10 serum.

It contains one of the best-documented collagen-stimulating compounds in cosmetic science, at a concentration most brands don’t bother with. The prestige labels sell you the same active for ten times the price, in nicer packaging, with a longer story attached.

This one is better. I’ll name it below.

(I ordered ten bottles before publishing this. I’d rather look paranoid than watch it sell out :)

Fair warning: The single biggest lever in this article is