🔬 Plasma Apheresis (FREE) vs. Full Plasma Exchange ($10k)

Free, paid, expensive, powerful, risky — which one truly biohacks your longevity?

🔄 Full Plasma Exchange vs. Plasmapheresis: What I Chose and Why

In the world of biohacking, full plasma exchange is quickly becoming the new “ultimate protocol” — right up there with red light therapy, cryotherapy, and hyperbaric oxygen therapy. Biohackers are lining up at cutting-edge wellness clinics to have their entire plasma volume replaced, often with plasma from anonymous donors.

I seriously considered doing it.

After diving deep into the scientific literature and connecting with a few centers like Next Health, I was ready to try full plasma exchange. But then I hit a wall: the price tag — $10,000 per session.

That’s when I paused.

Because I believe biohacking shouldn’t cost an arm and a leg, and there had to be a smarter, more accessible way. So I did what any self-respecting biohacker does: I researched harder.

I came across an article from Dave Pascoe, one of the OGs in the space. On his blog, he shares his journey with plasmapheresis (aka plasma donation by apheresis), and it completely shifted my perspective. I highly recommend reading his site — it’s full of no-BS, science-forward content. he does not spend $2M a year to turn back the aging clock like some cultish biohackers, yet he does look and sound decades younger!

🧠 Inspired, I went down the rabbit hole, reading 8 detailed medical studies (you’ll find the references at the end of this dossier).

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🤔 But Wait — Where Does Replacement Plasma Actually Come From?

Before committing to any form of plasma intervention, I had one pressing question:
Where does the “new” plasma come from in a full exchange?

🧪 1. Donor Plasma (FFP – Fresh Frozen Plasma)

• Collected from screened, healthy blood donors

• Contains clotting factors, antibodies, proteins

• Commonly used in autoimmune disorders, TTP, Guillain-Barré... and now by longevity seekers

• ⚠️ However, the screening process is not always fully transparent, and there’s a small but real risk of allergic reactions, infection, or immune responses

💧 2. Albumin + Saline (Most Common in Longevity Contexts)

• No actual donor plasma — just 5% human albumin (derived from pooled donors) mixed with saline

• Used in the Conboy plasma dilution protocol, which showed signs of reversing biomarkers of aging

• Cheaper, safer, no transfusion risks

• Helps clear pro-aging factors (like GDF-11, IL-6, TNF-alpha) while keeping you hydrated and balanced

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⚖️ One You Pay For, One Pays You

One boosts regeneration for free (you might even get paid 💸).
The other can cost thousands 💰.
One is widely accessible, the other demands clinical supervision and infrastructure.

So... which one gives better results? Should we do either of them?

Well — here’s my answer… at least for now.
I’ll let you in on what I chose and how it went in the next section because 🩸 Today I am getting my first….