The Ultimate Guide to Biohacking & Longevity

The Ultimate Guide to Biohacking & Longevity

The Biomarker That Predicts Mortality Better Than All Others—And Your Doctor Probably Isn't Testing It

Why This Matters for Biohackers....and I Find it Fascinating!

Valerie Orsoni Biohacker's avatar
Valerie Orsoni Biohacker
Jan 20, 2026
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For years, we’ve been tracking our biological age through expensive epigenetic tests like TruDiagnostic’s PACE or Horvath clocks.

While these DNA methylation tests are powerful, they’re also costly ($300-500 per test), require specialized labs, and aren’t something most people can access regularly through their standard healthcare.

Enter the Bortz model—a breakthrough biological age calculator published in Nature Communications Biology in October 2023 that achieves something remarkable: it estimates your biological age using just 25 standard blood biomarkers, the same ones your doctor likely orders in your annual physical.

And this is, to me, the most accurate model to date.. Let’s dig in….

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