The Ultimate Guide to Biohacking & Longevity

The Ultimate Guide to Biohacking & Longevity

Treatments

Waking Up Between 3am and 5am: The 8 Reasons Why Your Body Wakes You Up (And How To Fix It)

When your biological clock sounds the alarm: decoding hidden causes and optimization protocols

Valerie Orsoni Biohacker's avatar
Valerie Orsoni Biohacker
Feb 13, 2026
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You wake up systematically between 3am and 5am. Eyes wide open. Brain running at full speed. Impossible to fall back asleep before 6am... right when your alarm goes off.

Welcome to the very exclusive “3am crew” club.

Contrary to what pseudo-experts in Chinese medicine say (”It’s liver detox time”), there are precise physiological explanations for these nocturnal awakenings. And yes, you’re right: nocturnal hypoglycemia and cortisol spikes are the two main culprits.

But there are others. Many others.

I’ve dug into the scientific literature and tested several protocols on myself (and with my coaching clients). Here’s what I discovered.

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